The Epidemic

HIV Breakthrough

New antibody attacks 99% of strains. Human trials will start in 2018.

BY VICTOR MELAMED

Scientists have engineered an antibody that attacks 99% of HIV strains and can prevent infection in primates, reports bbc.com.

It is built to attack three critical parts of the virus—making it harder for HIV to resist its effects.

The work is a collaboration between the US National Institutes of Health and the pharmaceutical company Sanofi.

Human trials will start in 2018 to see if it can prevent or treat infection.

Our bodies struggle to fight HIV because of the virus’ incredible ability to mutate and change its appearance, explains BBC’s health and science reporter James Gallagher.

These varieties of HIV—or strains—in a single patient are comparable to those of influenza during a worldwide flu season.

So the immune system finds itself in a fight against an insurmountable number of strains of HIV.

But after years of infection, a small number of patients develop powerful weapons called “broadly neutralizing antibodies” that attack something fundamental to HIV and can kill large swathes of HIV strains.

Researchers have been trying to use broadly neutralizing antibodies as a way to treat HIV, or prevent infection in the first place.

The study, published in the journal Science, combines three such antibodies into an even more powerful “tri-specific antibody”.

Dr. Gary Nabel, the chief scientific officer at Sanofi and one of the report authors, told the BBC News website: “They are more potent and have greater breadth than any single naturally occurring antibody that’s been discovered.”

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